Skip to main content

Research and Projects

INTERPRESS-IPD: Inter-arm blood pressure difference, cardiovascular events, cerebrovascular disease and mortality: an Individual Patient Data meta-analysis

Who is involved?

Theme: CLAHRC - Diagnostics & Stratified Medicine
Status: Live


Inter-arm differences in blood pressure (IAD) are associated with increased cardiovascular and all-cause mortality in varied cohort studies.

INTERPRESS-IPD is an international collaboration to find out more about the link between IAD and mortality risk, by combining individual patient data (IPD) from IAD cohort studies into a single large dataset for IPD meta-analysis.

The project seeks to develop a new prognostic model for cardiovascular risk estimation that includes IAD, and to provide robust evidence on IAD to inform clinical care and future guidelines.

INTERPRESS-IPD is funded via the NIHR Research for Patient Benefit programme (PB-PG-0215-36009), and the PenCLAHRC Public Involvement Group (PenPIG) supported the funding bid. Find out more in the video above, or read our Exposure article.

Further information on INTERPRESS-IPD can be found on the University of Exeter Medical School website

Related projects

A previous PenCLAHRC-supported research project on hypertension helped to establish the prevalence of inter-arm blood pressure difference and its associations with peripheral vascular disease and reduced cardiovascular event-free survival. 

Find out more about this project on our news pages.

Related publications

Clark CE, Taylor RS, Butcher I, Stewart MCW, Price J, Fowkes FGR, Shore AC, Campbell JL. Inter-arm blood pressure difference and mortality: a cohort study in an asymptomatic primary care population at elevated cardiovascular risk. British Journal of General Practice 2016; DOI: 10.3399/bjgp16X684949

Clark CE, Steele AM, Taylor RS, Shore AC, Ukoumunne OC, Campbell JL. Interarm blood pressure difference in people with diabetes: measurement and vascular and mortality implications: a cohort study. Diabetes Care 2014 Jun; 37(6): 1631-1620.

Clark CE. The interarm blood pressure difference: Do we know enough yet? Journal of Clinical Hypertension 2017.

Others Involved

Dr Chris Clark, Prof John Campbell – Principal Investigators. Dr Fiona Warren, Prof Rod Taylor, Tim Eames, Prof Victor Aboyans, Prof Lyne Cloutier, Prof Richard McManus, Prof Angela Shore - Co-applicants. Julie Chudley - Research Administrator.